The human immunoglobulin pseudo-gamma IGHGP gene shows no major structural defect

A structural variant of the human interferon-gamma gene.

The first structural IFNG variant, G54D (c.287G>A, ss105106770), located in the second exon, was identified.

The human Rh50 glycoprotein gene. Structural organization and associated splicing defect resulting in Rh(null) disease.

The Rh (Rhesus) protein family comprises Rh50 glycoprotein and Rh30 polypeptides, which form a complex essential for Rh antigen expression and erythrocyte membrane integrity. This article describes the structural organization of Rh50 gene and identification of its associated splicing defect causing Rhnull disease. The Rh50 gene, which maps at chromosome 6p11-21.1, has an exon/intron structure n...

Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes.

BACKGROUND Characterization of the immunoglobulin gene repertoire has improved our understanding of the immunopathogenesis of lymphoid tumors. Early B-lymphocyte precursors of multiple myeloma are known to exist and might be susceptible to antigenic drive. DESIGN AND METHODS To verify this hypothesis, we collected a database of 345 fully readable multiple myeloma immunoglobulin sequences. We ...

Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus.

The cytotoxicity, and probably the selectivity, of folate antimetabolites depend upon the expression of the enzyme folylpoly-gamma-glutamate synthetase in tumor cells. Evidence for the existence of multiple forms of this enzyme and the need to define the control mechanisms determinant of expression levels in normal and neoplastic cells has focused attention on the gene(s) encoding these forms. ...

Structural units of human 7S gamma globulin.